Inherited

Released on 19/05/2016

Key Learning Points

  • Blood Transfusion
  • Bone Marrow Transplant
  • Desferrioxamine
  • Diagnosis of Thalassemia
  • Direct Coombs Test
  • Genetic Screening of Parents
  • Iron Chelation Therapy
  • Penicillamine
  • Phlebotomy
  • Prenatal Diagnosis
  • Splenectomy
  • Thalassemia

References

1. GALANELLO R, ORIGA R. Beta-thalassemia. Orphanet J Rare Dis [online] 2010 May 21:11 [viewed 19 January 2016] Available from: doi:10.1186/1750-1172-5-11
2. ORIGA R, PAGON RA, ADAM MP, ARDINGER HH, WALLACE SE, AMEMIYA A, BEAN LJH, BIRD TD, FONG CT, MEFFORD HC, SMITH RJH, STEPHENS K. Beta-Thalassemia [online] 1993 [viewed 19 January 2016] Available from: http://www.ncbi.nlm.nih.gov/pubmed/20301599
3. ORIGA R, MOI P, GALANELLO R, CAO A, PAGON RA, ADAM MP, ARDINGER HH, WALLACE SE, AMEMIYA A, BEAN LJH, BIRD TD, FONG CT, MEFFORD HC, SMITH RJH, STEPHENS K. Alpha-Thalassemia [online] 1993 [viewed 19 January 2016] Available from: http://www.ncbi.nlm.nih.gov/pubmed/20301608
4. DELOUGHERY THOMAS G.. Microcytic Anemia. N Engl J Med [online] 2014 October, 371(14):1324-1331 [viewed 19 January 2016] Available from: doi:10.1056/NEJMra1215361
5. ZANTEK ND, KOEPSELL SA, THARP DR JR, COHN CS. The direct antiglobulin test: a critical step in the evaluation of hemolysis. Am J Hematol [online] 2012 Jul, 87(7):707-9 [viewed 06 February 2016] Available from: doi:10.1002/ajh.23218
6. HOJO S, HUGUCHI M, ARAYA S. Glucan inhibition of diffusion in plaque. J Dent Res [online] 1976 Jan-Feb, 55(1):169 [viewed 10 February 2016] Available from: http://www.ncbi.nlm.nih.gov/pubmed/1426
7. ANGELUCCI E., MATTHES-MARTIN S., BARONCIANI D., BERNAUDIN F., BONANOMI S., CAPPELLINI M. D., DALLE J.-H., DI BARTOLOMEO P., DE HEREDIA C. D., DICKERHOFF R., GIARDINI C., GLUCKMAN E., HUSSEIN A. A., KAMANI N., MINKOV M., LOCATELLI F., ROCHA V., SEDLACEK P., SMIERS F., THURET I., YANIV I., CAVAZZANA M., PETERS C.. Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel. Haematologica [online] December, 99(5):811-820 [viewed 10 February 2016] Available from: doi:10.3324/haematol.2013.099747
8. LUCARELLI G, ISGRò A, SODANI P, GAZIEV J. Hematopoietic Stem Cell Transplantation in Thalassemia and Sickle Cell Anemia Cold Spring Harb Perspect Med [online] 2012/05/01 00:00, 2(5):a011825 [viewed 10 February 2016] Available from: doi:10.1101/cshperspect.a011825
9. LINDGREN FT, ADAMSON GL, JENSON LC, WOOD PD. Lipid and lipoprotein measurements in a normal adult American population. Lipids [online] 1975 Dec, 10(12):750-6 [viewed 10 February 2016] Available from: http://www.ncbi.nlm.nih.gov/pubmed/173963
10. FLORA SJ, PACHAURI V. Chelation in Metal Intoxication Int J Environ Res Public Health [online] 2010/07/01 00:00, 7(7):2745-2788 [viewed 09 February 2016] Available from: doi:10.3390/ijerph7072745